Researchers at UC Davis Health have discovered the potential cause of anxiety, which is often fueled by the decrease of hidden nutrients in the brain, in a new study.
The findings came from a meta-analysis of 25 previous studies that compared neurometabolite levels in 370 people with anxiety and 342 people without anxiety.
The levels of chemicals were measured using the non-invasive MRI technique called proton magnetic resonance spectroscopy.
According to results, published in Molecular Psychiatry, the individuals who struggle with anxiety issues typically have 8 percent low amounts of choline in their brains compared to those without anxiety disorders.
The drop in choline levels was most clearly observed in the prefrontal cortex, an area involved in thinking, decision-making and regulating emotions.
According to Jason Smucny, co-author of the study, “This is the first meta-analysis to demonstrate a chemical pattern in the brain in anxiety disorders. It suggests that nutritional approaches – such as appropriate choline supplementation – may help restore brain chemistry and improve outcomes for patients.”
The significant amount of choline is important for memory, mood, cell membranes and muscle control. It is produced in a very small amount in the body, making dietary intake necessary.
According to the researchers’ hypothesis, the possible cause of the lower levels of choline is related to increased flight-or-fight activity. As a result, it increases the brain’s demand for choline, decreasing available levels.
“We don’t know yet whether increasing choline in the diet will help reduce anxiety. More research will be needed,” Smucny added.
But a well-balanced diet with nutrients will support both physical and mental health.
