In a recent breakthrough in the fight against aging, scientists have discovered three hidden blood molecules that come from a blood-dwelling bacteria Paracoccus sanguinis ( P. sanguinis).
These naturally produced anti-aging compounds are rich in indole-functionalized metabolites.
These indole-based metabolites are the byproducts of Paracoccus sanguinisknown for their anti-inflammatory, anti-aging and antimicrobial properties.
Considering their broad-spectrum properties, Chung Sub Kim, Sullim Lee and their team developed the laboratory-grown culture of P. sanguinis and extracted indole metabolites from the culture.
According to Kim, “We got interested in it P. sanguinis because blood-derived microbes are a relatively unknown area of research.
“Given the unique environment of the bloodstream, we believed that studying individual species would be fun P. sanguinis could reveal previously unknown metabolic functions relevant to health and disease,” he added.
According to findings published in the Natural Products Magazine, Of the twelve extracted indole metabolites tested for anti-aging purposes, three, including two newly identified, have shown efficacy in reducing levels of cellular damage in human skin cell culture.
In addition, these molecules also reduced the amounts of two proteins associated with inflammation and a protein involved in collagen damage.
These hidden blood molecules also reduced the levels of reactive oxygen species in these stressed skin cells compared to untreated samples.
Based on these findings, the newly identified indole molecules with anti-aging power could pave the way for future skin therapies.
